CAS No.:67-48-1

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	25mg/kg (25mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog	LDLo	intravenous	5mg/kg (5mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog	LDLo	unreported	1500mg/kg (1500mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse	LD50	intraperitoneal	320mg/kg (320mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse	LD50	intravenous	53mg/kg (53mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse	LD50	oral	3900mg/kg (3900mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse	LDLo	subcutaneous	735mg/kg (735mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 6, Pg. 477, 1914/1915.
rabbit	LDLo	intraperitoneal	500mg/kg (500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.
rabbit	LDLo	intravenous	1100ug/kg (1.1mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit	LDLo	rectal	1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit	LDLo	subcutaneous	1gm/kg (1000mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rat	LD50	intraperitoneal	450mg/kg (450mg/kg)		Indian Journal of Experimental Biology. Vol. 24, Pg. 91, 1986.
rat	LD50	oral	3400mg/kg (3400mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Proceedings of the Society for Experimental Biology and Medicine. Vol. 58, Pg. 87, 1945.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes:  Xi
The Risk Statements information of  Choline chloride :
36/37/38:  Irritating to eyes, respiratory system and skin 
The Safety Statements information of  Choline chloride :
26:  In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice 
36:  Wear suitable protective clothing 
WGK Germany: 1
RTECS: KH2975000
F: 3-9

Standards and Recommendations：

 

Analytical Methods：