CAS No.:1333-82-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TCLo	inhalation	110ug/m3 (0.11mg/m3)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 291, 1980.
mouse	LD50	intraperitoneal	14mg/kg (14mg/kg)		Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 34, Pg. 193, 1979.
mouse	LD50	intravenous	17100ug/kg (17.1mg/kg)		Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
mouse	LD50	oral	127mg/kg (127mg/kg)		Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 14, Pg. 86, 1980.
mouse	LDLo	subcutaneous	20mg/kg (20mg/kg)		Senten Ijo. Congenital Anomalies. Vol. 19, Pg. 171, 1979.
rat	LD50	intraperitoneal	58400ug/kg (58.4mg/kg)		Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
rat	LD50	intravenous	9260ug/kg (9.26mg/kg)		Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
rat	LD50	oral	80mg/kg (80mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 27, Pg. 119, 1976.
rat	LDLo	skin	55mg/kg (55mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	National Technical Information Service. Vol. OTS0537097,

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: O,T+,N,T
Risk Statements: 45-46-9-24/25-26-35-42/43-48/23-50/53-62-8
R45:May cause cancer. 
R46:May cause heritable genetic damage. 
R9:Explosive when mixed with combustible material. 
R24:Toxic in contact with skin. 
R25 :Toxic if swallowed. 
R26:Very toxic by inhalation. 
R35:Causes severe burns. 
R42/43:May cause sensitization by inhalation and skin contact. 
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R8 :Contact with combustible material may cause fire. 
R62:Risk of impaired fertility.
Safety Statements: 53-45-60-61-36/37/39-28-26-22
S53:Avoid exposure - obtain special instructions before use. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S60:This material and its container must be disposed of as hazardous waste. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S28:After contact with skin, wash immediately with plenty of soap-suds. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S22:Do not breathe dust.
RIDADR: UN 1463 5.1/PG 2
WGK Germany: 3
RTECS: GB6650000
HazardClass: 5.1
PackingGroup: II
HS Code: 28191000

Standards and Recommendations：

 

Analytical Methods：