CAS No.:5786-21-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	4762ug/kg (4.762mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: ANTIPSYCHOTIC	American Journal of Emergency Medicine. Vol. 14, Pg. 462, 1996.
dog	LD50	oral	145mg/kg (145mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
guinea pig	LD50	oral	510mg/kg (510mg/kg)		Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
human	TDLo	oral	5mg/kg/7D-I (5mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 919, 1972.
man	TDLo	oral	4286ug/kg/11D (4.286mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)	Journal of Clinical Pyschopharmacology. Vol. 13, Pg. 155, 1993.
man	TDLo	oral	5357ug/kg/5D- (5.357mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ANTIPSYCHOTIC CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Journal of Clinical Pyschopharmacology. Vol. 12, Pg. 139, 1992.
man	TDLo	oral	27mg/kg/13D-I (27mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ATAXIA	Journal of Clinical Psychiatry. Vol. 55, Pg. 38, 1994.
man	TDLo	oral	40mg/kg (40mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Veterinary and Human Toxicology. Vol. 41, Pg. 20, 1999.
man	TDLo	oral	86mg/kg/15D-I (86mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	British Journal of Psychiatry. Vol. 173, Pg. 440, 1998.
man	TDLo	oral	270mg/kg/6W-I (270mg/kg)	LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI BLOOD: AGRANULOCYTOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Annales de Medecine Interne. Vol. 144, Pg. 494, 1993.
man	TDLo	oral	429mg/kg/60D- (429mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	American Journal of Psychiatry. Vol. 152, Pg. 649, 1995.
man	TDLo	oral	429mg/kg (429mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: COMA	Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 325, 2000.
man	TDLo	oral	2211mg/kg/37W (2211mg/kg)	BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Journal of Clinical Pyschopharmacology. Vol. 15, Pg. 287, 1995.
man	TDLo	oral	3280mg/kg/82W (3280mg/kg)	BLOOD: AGRANULOCYTOSIS	American Journal of Psychiatry. Vol. 153, Pg. 1503, 1996.
mouse	LD50	intraperitoneal	90mg/kg (90mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
mouse	LD50	intravenous	36500ug/kg (36.5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
mouse	LD50	oral	150mg/kg (150mg/kg)		Journal of Medicinal Chemistry. Vol. 23, Pg. 878, 1980.
mouse	LD50	subcutaneous	194mg/kg (194mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
rat	LD50	intramuscular	210mg/kg (210mg/kg)		Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
rat	LD50	intravenous	41600ug/kg (41.6mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
rat	LD50	oral	251mg/kg (251mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
rat	LD50	subcutaneous	240mg/kg (240mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 667, 1973.
women	TDLo	oral	20mg/kg (20mg/kg)	BEHAVIORAL: COMA BLOOD: LEUKOPENIA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS	Annals of Internal Medicine. Vol. 121, Pg. 722, 1994.
women	TDLo	oral	28mg/kg/2W-I (28mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS	Lancet. Vol. 340, Pg. 251, 1992.
women	TDLo	oral	96mg/kg/48D-I (96mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS	Human Psychopharmacology. Vol. 13, Pg. 583, 1998.
women	TDLo	oral	104mg/kg/26D- (104mg/kg)	BLOOD: EOSINOPHILIA	Journal of Clinical Psychiatry. Vol. 59, Pg. 195, 1998.
women	TDLo	oral	168mg/kg/4W-I (168mg/kg)	BLOOD: AGRANULOCYTOSIS	Netherlands Journal of Medicine. Vol. 52, Pg. 26, 1998.
women	TDLo	oral	280mg/kg/5W-I (280mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" BLOOD: EOSINOPHILIA	American Journal of Psychiatry. Vol. 150, Pg. 985, 1993.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38 
R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Standards and Recommendations：

 

Analytical Methods：