CAS No.:67-68-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	100mg/kg (100mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
cat	LDLo	intravenous	200mg/kg (200mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1571, 1978.
chicken	LD50	oral	12gm/kg (12000mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963.
dog	LD50	intravenous	2500mg/kg (2500mg/kg)	CARDIAC: OTHER CHANGES KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Cancer Chemotherapy Reports. Vol. 31, Pg. 7, 1963.
dog	LD50	oral	> 10gm/kg (10000mg/kg)		Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967.
guinea pig	LDLo	intraperitoneal	> 5500mg/kg (5500mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963.
guinea pig	LDLo	oral	> 11gm/kg (11000mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963.
mammal (species unspecified)	LD50	oral	21400mg/kg (21400mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
man	TDLo	intravenous	606mg/kg (606mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"	Lancet. Vol. 2, Pg. 1004, 1980.
mouse	LD50	intraperitoneal	2500mg/kg (2500mg/kg)		Russian Pharmacology and Toxicology Vol. 35, Pg. 300, 1972.
mouse	LD50	intravenous	3100mg/kg (3100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE	Toxicology and Applied Pharmacology. Vol. 15, Pg. 74, 1969.
mouse	LD50	oral	7920mg/kg (7920mg/kg)		Chimica Therapeutica. Vol. 3, Pg. 10, 1968.
mouse	LD50	skin	50gm/kg (50000mg/kg)		Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967.
mouse	LD50	subcutaneous	14gm/kg (14000mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: HEMATURIA	Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967.
mouse	LD50	unreported	12gm/kg (12000mg/kg)		United States Patent Document. Vol. #4767763,
rat	LD50	intraperitoneal	8200mg/kg (8200mg/kg)		Food and Chemical Toxicology. Vol. 22, Pg. 665, 1984.
rat	LD50	intravenous	5360mg/kg (5360mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS	Toxicology and Applied Pharmacology. Vol. 7, Pg. 104, 1965.
rat	LD50	oral	14500mg/kg (14500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE	Toxicology and Applied Pharmacology. Vol. 15, Pg. 74, 1969.
rat	LD50	skin	40gm/kg (40000mg/kg)		Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967.
rat	LD50	subcutaneous	12gm/kg (12000mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1050, 1964.
rat	LD50	unreported	1300mg/kg (1300mg/kg)		National Technical Information Service. Vol. AD-A159-418,
women	TDLo	skin	1800mg/kg (1800mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: OTHER CHANGES	Veterinary and Human Toxicology. Vol. 40, Pg. 87, 1998.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes of Dimethyl sulfoxide (CAS NO.67-68-5): Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-37/39-26-36-23
S24/25:Avoid contact with skin and eyes. 
S37/39:Wear suitable gloves and eye/face protection. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S23:Do not breathe vapour.
WGK Germany: 1
RTECS: PV6210000
F: 3
HS Code: 29309070

Standards and Recommendations：

 

Analytical Methods：