CAS No.:138729-47-2

TOXICITY DATA with REFERENCE：

 

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Analytical Methods：EsZOPICLONE acts on benzodiazepine "receptors" on GABA neurons as an agonist.[4] EsZOPICLONE is rapidly absorbed after oral administration, with serum levels peaking between 1 and 1.3 hours.[5] The elimination half-life of esZOPICLONE is approximately 6 hours and is extensively metabolized by oxidation and demethylation. Approximately 52% to 59% of a dose is weakly bound to plasma protein. Cytochrome P450 (CYP) isozymes CYP3A4 and CYP2E1 are involved in the biotransformation of esZOPICLONE; thus, drugs that induce or inhibit these CYP isozymes may affect the metabolism of esZOPICLONE. Less than 10% of the orally administered dose is excreted in the urine as racemic ZOPICLONE.[6] In terms of benzodiazepine receptor binding and relevant potency, 3 mg of esZOPICLONE is equivalent to 10 mg of DIAZEPAM.[7]