CAS No.:41340-25-4
Name: Etodolac
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | oral | > 4gm/kg (4000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990. |
mouse | LD50 | intraperitoneal | 338mg/kg (338mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990. |
mouse | LD50 | oral | 593mg/kg (593mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990. |
mouse | LD50 | subcutaneous | 502mg/kg (502mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990. |
rat | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990. |
rat | LD50 | oral | 94mg/kg (94mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990. |
rat | LD50 | subcutaneous | 113mg/kg (113mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 469, 1990. |
Consensus Reports:
SAFETY PROFILE:
Hazard Codes: T,
Xi
Risk Statements: 23/24/25-40-36-25-36/37/38
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R40: Limited evidence of a carcinogenic effect.
R36: Irritating to eyes.
R25: Toxic if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-36-45-26-36/37
S22: Do not breathe dust.
S36: Wear suitable protective clothing.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
RIDADR: 3249
WGK Germany: 3
RTECS: UQ0360000
HazardClass: 6.1(b)
PackingGroup: III
Standards and Recommendations:
Analytical Methods:
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