CAS No.:2022-85-7

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD12	oral	500mg/kg (500mg/kg)		British UK Patent Application. Vol. #2067993,
mouse	LD50	intraperitoneal	1190mg/kg (1190mg/kg)		Antimicrobial Agents and Chemotherapy Vol. -, Pg. 566, 1963.
mouse	LD50	intravenous	500mg/kg (500mg/kg)		Antimicrobial Agents and Chemotherapy Vol. -, Pg. 566, 1963.
mouse	LD50	subcutaneous	1gm/kg (1000mg/kg)		Chemotherapy Vol. 25, Pg. 54, 1979.
rat	LD50	intraperitoneal	3811mg/kg (3811mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979.
rat	LD50	intravenous	> 600mg/kg (600mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979.
rat	LD50	oral	> 15gm/kg (15000mg/kg)		Drugs in Japan Vol. 6, Pg. 699, 1982.
rat	LD50	subcutaneous	3336mg/kg (3336mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 935, 1979.
women	TDLo	oral	1080mg/kg/10D (1080mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA	European Journal of Clinical Pharmacology. Vol. 51, 505.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn,Xi ;T
Risk Statements: 40-36/37/38 
R40:Limited evidence of a carcinogenic effect. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-45-36/37-36/37/39-27-26 
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37:Wear suitable protective clothing and gloves. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S27:Take off immediately all contaminated clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 2
RTECS: HA6040000
F: 10-23
Hazard Note: Toxic/Light Sensitive
HazardClass: IRRITANT, LIGHT SENSITIVE

Standards and Recommendations：

 

Analytical Methods：