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CAS No.:59-30-3

Name: Folic Acid

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 120mg/kg (120mg/kg)   Drugs in Japan Vol. -, Pg. 1409, 1995.
mouse LD50 intraperitoneal 85mg/kg (85mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: COMA
Experientia. Vol. 41, Pg. 72, 1985.
mouse LD50 intravenous 282mg/kg (282mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.
mouse LD50 oral 10gm/kg (10000mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.
mouse LDLo subcutaneous 200mg/kg (200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

BLOOD: CHANGES IN SPLEEN
Proceedings of the Society for Experimental Biology and Medicine. Vol. 71, Pg. 544, 1949.
rabbit LD50 intravenous 410mg/kg (410mg/kg)   Drugs in Japan Vol. -, Pg. 1409, 1995.
rat LD50 intravenous 500mg/kg (500mg/kg)   Drugs in Japan Vol. -, Pg. 1409, 1995.


Consensus Reports:

 


SAFETY PROFILE:

Risk Statements: 33-62-68
R33: Danger of cumulative effects. 
R62: Risk of impaired fertility. 
R68: Possible risk of irreversible effects.
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: LP5425000
F: 8


Standards and Recommendations:

 


Analytical Methods:

 


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