CAS No.:1405-41-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	subcutaneous	600mg/kg (600mg/kg)		Chemotherapy Vol. 16, Pg. 105, 1968.
man	TDLo	intravenous	21mg/kg/6D-I (21mg/kg)		Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 596, 1984.
mouse	LD50	intracrebral	17300ug/kg (17.3mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE	Chemotherapy Vol. 15, Pg. 483, 1967.
mouse	LD50	intramuscular	250mg/kg (250mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
mouse	LD50	intraperitoneal	245mg/kg (245mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
mouse	LD50	intravenous	47mg/kg (47mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse	LD50	oral	> 11269mg/kg (11269mg/kg)		Drugs in Japan Vol. 6, Pg. 268, 1982.
mouse	LD50	subcutaneous	478mg/kg (478mg/kg)		Journal of Antibiotics. Vol. 23, Pg. 551, 1970.
rat	LD50	intramuscular	384mg/kg (384mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD50	intraperitoneal	630mg/kg (630mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Antibiotics. Vol. 26, Pg. 221, 1973.
rat	LD50	intravenous	96mg/kg (96mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
rat	LD50	oral	> 5gm/kg (5000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
rat	LD50	subcutaneous	873mg(base)/k (873mg/kg)		Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(9), Pg. 26, 1990.
women	TDLo	intravenous	45mg/kg/1W-I (45mg/kg)		Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 596, 1984.

Consensus Reports：

 

SAFETY PROFILE：

GENTAMYCIN sulfate's human systemic effects: level changes for metals other than Na/K/Fe/Ca/P/Cl. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO_x.
Hazard Symbols of Gentamycin sulfate (CAS NO.1405-41-0): Xn 
Risk Codes: R42/43 
R42/43:May cause sensitization by inhalation and skin contact. 
Safety Description: S23;S36/37;S45 
S23:Do not breathe vapour. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Standards and Recommendations：

 

Analytical Methods：