CAS No.:75-31-0
Name: Isopropylamine
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 2700mg/kg (2700mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980. | |
mammal (species unspecified) | LC50 | inhalation | 1800mg/m3 (1800mg/m3) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975. | |
mammal (species unspecified) | LD50 | unreported | 500mg/kg (500mg/kg) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975. | |
mouse | LCLo | inhalation | 7000ppm/40M (7000ppm) | Shell Chemical Company. Unpublished Report. Vol. -, Pg. 7, 1961. | |
mouse | LD50 | oral | 2200mg/kg (2200mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980. | |
rabbit | LD50 | oral | 3200mg/kg (3200mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980. |
rabbit | LD50 | skin | 380mg/kg (380mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
rat | LC50 | inhalation | 4000ppm/4H (4000ppm) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
rat | LD50 | oral | 111mg/kg (111mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: OTHER CHANGES |
National Technical Information Service. Vol. OTS0542011, |
rat | LDLo | intraperitoneal | 50mg/kg (50mg/kg) | Farmakologiya i Toksikologiya Vol. 31, Pg. 238, 1968. |
Consensus Reports:
Isopropylamine (CAS NO.75-31-0) can be obtained by aminating isopropyl alcohol with ammonia in presence of a nickel/copper or similar catalyst:
(CH3)2CHOH + NH3 → (CH3)2CHNH2 + H2O
SAFETY PROFILE:
Hazard Codes: F+,Xi
Risk Statements: 12-36/37/38
R12:Extremely flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-29
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S29:Do not empty into drains.
RIDADR: UN 1221 3/PG 1
WGK Germany: 1
RTECS: NT8400000
F: 34
HazardClass: 3
PackingGroup: I
Standards and Recommendations:
Analytical Methods:
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