CAS No.:121-75-5

TOXICITY DATA with REFERENCE：

1.		mmo-sat 10 mg/L		TGANAK    Tsitologiya i Genetika. 15 (3)(1981),68.
2.		sce-hmn:lym 40 mg/L		MUREAV    Mutation Research. 88 (1981),307.
3.		orl-man LDLo:471 mg/kg:CNS,CVS,PUL		ATXKA8    Archiv fuer Toxikologie. 23 (1967),11.
4.		orl-wmn LDLo:246 mg/kg		AEHLAU    Archives of Environmental Health. 33 (1978),240.
5.		orl-rat LD50:290 mg/kg		85GMAT    Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,56.
6.		ihl-rat LC50:43,790 µg/m3/4H		GISAAA    Gigiena i Sanitariya. 56 (2)(1991),80.
7.		ipr-rat LD50:250 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 22 (1972),1926.
8.		scu-rat LD50:1000 mg/kg		JEENAI    Journal of Economic Entomology. 50 (1957),356.
9.		ivn-rat LD50:50 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 5 (1955),626.
10.		orl-mus LD50:190 mg/kg		85GMAT    Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmero

 

Consensus Reports：

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal No Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 30 ,1983,p. 103.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-24 ,1978. ; No Evidence: rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-192 ,1979. . EPA Genetic Toxicology Program.

SAFETY PROFILE：

A human poison by ingestion and skin contact. Can penetrate intact skin. An experimental poison by ingestion, inhalation, intraperitoneal, intravenous, intraarterial, and subcutaneous routes. Human systemic effects by ingestion: coma, blood pressure depression, and difficulty in breathing. Questionable carcinogen. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Has caused allergic sensitization of the skin. An organic phosphate cholinesterase inhibitor. When heated to decomposition it emits toxic fumes of PO_x and SO_x. See also PHOSPHATES and PARATHION.
Hazard Codes: Xn;N;F
Risk Statements: 22-50/53-67-65-38-11
22:  Harmful if swallowed 
50/53:  Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment 
67:  Vapors may cause drowsiness and dizziness 
65:  Harmful: May cause lung damage if swallowed 
38:  Irritating to the skin 
11:  Highly Flammable
Safety Statements: 2-24-60-61-62
2:  Keep out of the reach of children 
24:  Avoid contact with skin 
60:  This material and/or its container must be disposed of as hazardous waste 
61:  Avoid release to the environment. Refer to special instructions safety data sheet 
62:  If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label
RIDADR:  UN 2783
HazardClass:  6.1(b)

Standards and Recommendations：

OSHA PEL: TWA Total Dust: 10 mg/m³; Respirable Fraction: 5 mg/m³ (skin)
ACGIH TLV: TWA 1 mg/m³ (skin); Not Classifiable as a Human Carcinogen
DFG MAK: 15 mg/m³
NIOSH REL: (Malathion) TWA 15 mg/m³

Analytical Methods：