CAS No.:7718-54-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	11mg/kg (11mg/kg)		Toxicology. Vol. 64, Pg. 19, 1990.
mouse	LD50	intravenous	20mg/kg (20mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
mouse	LD50	oral	369mg/kg (369mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
rabbit	LD50	intramuscular	27mg/kg (27mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 119, 1946.
rat	LD50	intraperitoneal	20597ug/kg (20.597mg/kg)		Toxicology. Vol. 35, Pg. 47, 1985.
rat	LD50	intravenous	68100ug/kg (68.1mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
rat	LD50	oral	681mg/kg (681mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes TN,Xi
Risk Statements 45-25-36/38-43-50/53-22-52
R22:Harmful if swallowed. 
R25 :Toxic if swallowed. 
R45:May cause cancer. 
R43:May cause sensitization by skin contact.
R36/38:Irritating to eyes and skin. 
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R52:Harmful to aquatic organisms.
Safety Statements 53-26-36/37-45-61-29-24 
S53:Avoid exposure - obtain special instructions before use. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets. 
S29:Do not empty into drains. 
S24:Avoid contact with skin.
RIDADR UN 3288 6.1/PG 3
WGK Germany 3
RTECS QR6475000
F 3
HazardClass 6.1(b)
PackingGroup III

Standards and Recommendations：

 

Analytical Methods：