CAS No.:70458-96-7

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	oral	> 4gm/kg (4000mg/kg)		Journal of Medicinal Chemistry. Vol. 32, Pg. 671, 1989.
man	TDLo	oral	94mg/kg/13D-I (94mg/kg)	MUSCULOSKELETAL: OTHER CHANGES	New Zealand Medical Journal. Vol. 96, Pg. 590, 1983.
mouse	LD50	intramuscular	470mg/kg (470mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Chemotherapy Vol. 29(Suppl,
mouse	LD50	intraperitoneal	1064mg/kg (1064mg/kg)		Ensho. Japanese Journal of Inflammation. Vol. 11, Pg. 343, 1991.
mouse	LD50	intravenous	220mg/kg (220mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Chemotherapy Vol. 29(Suppl,
mouse	LD50	oral	4gm/kg (4000mg/kg)		Journal of Medicinal Chemistry. Vol. 30, Pg. 2163, 1987.
mouse	LD50	subcutaneous	> 1500mg/kg (1500mg/kg)		Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984.
rat	LD50	intramuscular	> 500mg/kg (500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Chemotherapy Vol. 29(Suppl,
rat	LD50	intravenous	245mg/kg (245mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Chemotherapy Vol. 29(Suppl,
rat	LD50	oral	> 4gm/kg (4000mg/kg)		Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984.
rat	LD50	subcutaneous	> 1500mg/kg (1500mg/kg)		Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984.
women	TDLo	oral	48mg/kg/2D-I (48mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: LIVER FUNCTION TESTS IMPAIRED	Medical Journal of Australia. Vol. 159, Pg. 423, 1993.
women	TDLo	oral	48mg/kg/2D-I (48mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" BEHAVIORAL: MUSCLE WEAKNESS MUSCULOSKELETAL: JOINTS	Medical Journal of Australia. Vol. 159, Pg. 423, 1993.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: VB2005000

Standards and Recommendations：

 

Analytical Methods：