CAS No.:135159-51-2
Name: Sarpogrelate hydrochloride
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 3gm/kg (3000mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl, |
| mouse | LD50 | intraperitoneal | 65mg/kg (65mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: PERITONITIS |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl, |
| mouse | LD50 | intravenous | > 45mg/kg (45mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl, |
| mouse | LD50 | oral | 2550mg/kg (2550mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl, |
| rat | LD50 | intraperitoneal | 108mg/kg (108mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: PERITONITIS |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl, |
| rat | LD50 | intravenous | > 45mg/kg (45mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl, |
| rat | LD50 | oral | 4400mg/kg (4400mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl, |
Consensus Reports：
SAFETY PROFILE：
Standards and Recommendations：
Analytical Methods：
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