CAS No.:738-70-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	90mg/kg (90mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Chemotherapy Vol. 14, Pg. 37, 1969.
mouse	LD50	intraperitoneal	400mg/kg (400mg/kg)		Toksikologicheskii Vestnik. Vol. (2), Pg. 34, 1998.
mouse	LD50	intravenous	132mg/kg (132mg/kg)		Journal of Chemotherapy. Vol. 5, Pg. 400, 1993.
mouse	LD50	oral	2764mg/kg (2764mg/kg)		United States Patent Document. Vol. #4180578,
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Chemotherapy Vol. 21, Pg. 175, 1973.
rat	LD50	intraperitoneal	500mg/kg (500mg/kg)		Toksikologicheskii Vestnik. Vol. (2), Pg. 34, 1998.
rat	LD50	oral	> 5300mg/kg (5300mg/kg)		Toksikologicheskii Vestnik. Vol. (2), Pg. 34, 1998.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Chemotherapy Vol. 21, Pg. 175, 1973.
women	TDLo	oral	56mg/kg/7D-I (56mg/kg)	KIDNEY, URETER, AND BLADDER: HEMATURIA BLOOD: OTHER CHANGES MUSCULOSKELETAL: JOINTS	Postgraduate Medical Journal. Vol. 68, Pg. 391, 1992.
women	TDLo	oral	60mg/kg/10D-I (60mg/kg)	BLOOD: THROMBOCYTOPENIA	New Zealand Medical Journal. Vol. 106, Pg. 251, 1993.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: T
Risk Statements: 25 
R25: Toxic if swallowed
Safety Statements: 45 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 3249
WGK Germany: 3
RTECS: UV8225000
F: 8-10-21 
F 8: Photosensitive
F 10: Keep under argon
F 21: Sensitive to humidity
HazardClass: 6.1(b)
PackingGroup: III 
Use of 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine (CAS NO.738-70-5) is contraindicated during pregnancy, especially the first trimester, and for sufferers of certain blood disorders. It is contraindicated to use trimethoprim during pregnancy, especially the first trimester, and for sufferers of certain blood disorders. 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine (CAS NO.738-70-5) also may be involved in a reaction similar to disulfiram when alcohol is consumed after it is used, particularly when used in combination with sulfamethoxazole .It can also reduce clearance of creatinine at renal tubules.

Standards and Recommendations：

 

Analytical Methods：