CAS No.:110-57-6
Name: trans-1,4-Dichloro-2-butene
Details Introduction
TOXICITY DATA with REFERENCE:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source | 
|---|---|---|---|---|---|
| rat | LC50 | inhalation | 86ppm/4H (86ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS  | 
                    Annual Meeting of American Industrial Hygiene Association. Vol. -, Pg. -, 1968. | 
Consensus Reports:
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 (1977),p. 149.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.
SAFETY PROFILE:
A poison by inhalation. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. When heated to decomposition it emits toxic fumes of Cl−. 
        Hazard Codes: 
  T+,
T, 
  F, 
  N 
        HazardClass: 6.1(a) 
        Risk Statements: 
        10:  Flammable  
        11:  Highly Flammable  
        21:  Harmful in contact with skin  
        25:  Toxic if swallowed  
        26:  Very Toxic by inhalation  
        34:  Causes burns  
        45:  May cause cancer  
        39/23/24/25:  Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed  
        23/24/25:  Toxic by inhalation, in contact with skin and if swallowed  
        24/25:  Toxic in contact with skin and if swallowed  
        Safety Statements:
        23:  Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)  
        26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice  
        60:  This material and/or its container must be disposed of as hazardous waste  
        61:  Avoid release to the environment. Refer to special instructions safety data sheet  
        36/37:  Wear suitable protective clothing and gloves  
        36/37/39:  Wear suitable protective clothing, gloves and eye/face protection  
        RIDADR: UN 3390 6.1/PG 1
        WGK Germany: 3
        RTECS: EM4903000
        F: 8-21 
        PackingGroup: II
Standards and Recommendations:
Analytical Methods:
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