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Current position:Home > Products > 1-(p-CHLOROPHENYL)-5-ISOPROPYLBI GUANIDE HYDROCHLORIDE

CAS No.:637-32-1

Name: 1-(p-CHLOROPHENYL)-5-ISOPROPYLBI GUANIDE HYDROCHLORIDE

Details Introduction

TOXICITY DATA with REFERENCE:

1.    

orl-rat LD50:58 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
2.    

ivn-rat LD50:33 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
3.    

orl-mus LD50:27 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
4.    

ivn-mus LD50:23 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
5.    

orl-rbt LD50:172 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 2 (1947),181.
6.    

ivn-rbt LD50:44,850 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
7.    

ivn-gpg LD50:39,510 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
8.    

orl-ckn LD50:400 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 2 (1947),181.

Consensus Reports:

 


SAFETY PROFILE:

Poison by ingestion and intravenous routes. Experimental reproductive effects. An antimalarial drug. When heated to decomposition it emits very toxic fumes of Cl and NOx.Safety information of Proguanil hydrochloride (CAS NO.637-32-1):
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III


Standards and Recommendations:

 


Analytical Methods:

 


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