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CAS No.:19408-74-3

Name: 1,2,3,7,8,9-Hexachlorodibenzo-P-Dioxin

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Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 60ug/kg (0.06mg/kg)   Toxicology and Applied Pharmacology. Vol. 44, Pg. 335, 1978.
mouse LD50 oral > 1440mg/kg (1440mg/kg) Endocrine: changes in spleen weight endocrine: changes in thymus weight blood: "changes in serum composition (e.g., tp, bilirubin, cholesterol)" Toxicology and Applied Pharmacology. Vol. 44, Pg. 335, 1978.

Consensus Reports:

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 , 1977,p. 41.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human No Adequate Data IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 , 1977,p. 41.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .


SAFETY PROFILE:

A poison by ingestion. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic vapors of Cl
RIDADR: 2811
HazardClass: 6.1(a)
PackingGroup: I


Standards and Recommendations:

 


Analytical Methods:

 


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