CAS No.:1492-18-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1036mg/kg (1036mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse	LD50	intravenous	732mg/kg (732mg/kg)		Drugs in Japan Vol. 6, Pg. 910, 1982.
mouse	LD50	oral	> 7gm/kg (7000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat	LD50	intraperitoneal	1063mg/kg (1063mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat	LD50	oral	> 8gm/kg (8000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn
Risk Statements about Folinic acid (CAS No.1492-18-8):
R42/43: May cause sensitization by inhalation and skin contact. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements:
S22: Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing. 
S36/37: Wear suitable protective clothing and gloves.
Attention:
1. Storage: Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 °C). Store protected from light and air.
2. Handling: Wash hands before eating. Use only in a well ventilated area. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Keep container tightly closed. Store protected from light. Use and store under nitrogen. Store and handle protected from air. Wash clothing before reuse. Discard contaminated shoes.

Standards and Recommendations：

 

Analytical Methods：