CAS No.:57-57-8

TOXICITY DATA with REFERENCE：

1.		slt-dmg-orl 200 mmol/L		ENMUDM    Environmental Mutagenesis. 6 (1984),153.
2.		otr-hmn:fbr 28 µmol/L		PNASA6    Proceedings of the National Academy of Sciences of the United States of America. 80 (1983),7219.
3.		ihl-rat LC50:25 ppm/6H		DTLVS*    Documentation of Threshold Limit Values for Substances in Workroom Air. 4 (1980),347.
4.		ipr-mus LD50:405 mg/kg		JJIND8    JNCI, Journal of the National Cancer Institute. 62 (1979),911.

Consensus Reports：

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 4 ,1974,p. 259.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Community Right-To-Know List. EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by inhalation. Moderately toxic by intraperitoneal route. An initiator. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
T+: Very toxic
Risk Statements about β-Propiolactone (57-57-8):
R45 May cause cancer. 
R26 Very toxic by inhalation. 
R36/38 Irritating to eyes and skin.
Safety Statements about β-Propiolactone (57-57-8):
S53 Avoid exposure - obtain special instructions before use. 
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). 
Attentions:
1. Storage: Keep away from sources of ignition. Store in a tightly closed container. Deep freeze (below -20 C). Store protected from light. Store under argon.
2. Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.

Standards and Recommendations：

OSHA PEL: OSHA: Carcinogen
ACGIH TLV: TWA 0.5 ppm; Animal Carcinogen
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen

Analytical Methods：