CAS No.:126-07-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	280mg/kg (280mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 44, 1960.
mouse	LD50	oral	> 50gm/kg (50000mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 44, 1960.
mouse	LD50	subcutaneous	> 12gm/kg (12000mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 44, 1960.
rat	LD50	intraperitoneal	> 5gm/kg (5000mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 44, 1960.
rat	LD50	intravenous	400mg/kg (400mg/kg)	BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Nature. Vol. 182, Pg. 1320, 1958.
rat	LD50	oral	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. 6, Pg. 215, 1982.

Consensus Reports：

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 , 1976,p. 153.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

SAFETY PROFILE：

Hazard Codes of Griseofulvin (CAS NO.126-07-8): T,Xn
Risk Statements: 60-61-40-43-45 
R60: May impair fertility. 
R61: May cause harm to the unborn child. 
R40: Limited evidence of a carcinogenic effect. 
R43: May cause sensitization by skin contact. 
R45: May cause cancer.
Safety Statements: 53-22-36/37/39-45 
S53: Avoid exposure - obtain special instructions before use. 
S22: Do not breathe dust. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: WG9800000
Confirmed carcinogen with experimental neoplastigenic and teratogenic data. Poison by intravenous and intraperitoneal routes. Moderately toxic by subcutaneous route. Human mutation data reported. Experimental reproductive effects. Used as an antibiotic, pharmaceutical, and veterinary drug. When heated to decomposition it emits toxic fumes of Cl⁻.

Standards and Recommendations：

 

Analytical Methods：