CAS No.:102-06-7

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	25mg/kg (25mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TETANY	Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 143, Pg. 815, 1949.
guinea pig	LD50	oral	250mg/kg (250mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 974, 1986.
guinea pig	LDLo	subcutaneous	200mg/kg (200mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TETANY	Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 143, Pg. 815, 1949.
mammal (species unspecified)	LDLo	oral	250mg/kg (250mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Industrial Hygiene. Vol. 13, Pg. 87, 1931.
mouse	LD50	intraperitoneal	25mg/kg (25mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	oral	150mg/kg (150mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: ATAXIA	Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.
mouse	LD50	unreported	258mg/kg (258mg/kg)	BLOOD: NORMOCYTIC ANEMIA	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(7), Pg. 35, 1978.
rabbit	LD50	oral	250mg/kg (250mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 974, 1986.
rabbit	LD50	skin	> 794mg/kg (794mg/kg)		National Toxicology Program Technical Report Series. Vol. NIH-95-3933,
rabbit	LD50	unreported	246mg/kg (246mg/kg)	BLOOD: NORMOCYTIC ANEMIA	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(7), Pg. 35, 1978.
rat	LD50	intraperitoneal	75mg/kg (75mg/kg)		Medycyna Pracy. Industrial Medicine. Vol. 16, Pg. 35, 1965.
rat	LD50	oral	323mg/kg (323mg/kg)		National Toxicology Program Technical Report Series. Vol. NIH-95-3933,
rat	LD50	unreported	323mg/kg (323mg/kg)	BLOOD: NORMOCYTIC ANEMIA	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(7), Pg. 35, 1978.

Consensus Reports：

Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Poison by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Xn,N
Risk Statements : 
R22:Harmful if swallowed.;
R36/37/38:Irritating to eyes, respiratory system and skin.;
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.;
R62:Possible risk of impaired fertility.;
Safety Statements : 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.;
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.;
S61:Avoid release to the environment. Refer to special instructions / Safety data sheets.;
RIDADR: UN 3077 9/PG 3

Standards and Recommendations：

 

Analytical Methods：