CAS No.:80-08-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	357mg/kg (357mg/kg)		Archives of Neurology and Psychiatry. Vol. 54, Pg. 319, 1945.
child	TDLo	oral	5mg/kg (5mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicology, Clinical Toxicology. Vol. 19, Pg. 1061, 1982/1983.
child	TDLo	oral	37500ug/kg (37.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Pediatric Emergency Care. Vol. 13, Pg. 127, 1997.
domestic animals - goat/sheep	LDLo	unreported	200mg/kg (200mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	British Journal of Pharmacology and Chemotherapy. Vol. 5, Pg. 565, 1950.
guinea pig	LD50	oral	300mg/kg (300mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.
human	TDLo	oral	18gm/kg/15Y (18000mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES MUSCULOSKELETAL: JOINTS	British Medical Journal. Vol. 1, Pg. 78, 1978.
mammal (species unspecified)	LD50	unreported	1400mg/kg (1400mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 23, 1978.
man	TDLo	oral	36mg/kg (36mg/kg)	BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Human Toxicology. Vol. 2, Pg. 507, 1983.
mouse	LD50	intraperitoneal	313mg/kg (313mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952.
mouse	LD50	intravenous	225mg/kg (225mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952.
mouse	LD50	oral	250mg/kg (250mg/kg)		American Review of Tuberculosis. Vol. 60, Pg. 62, 1949.
mouse	LD50	subcutaneous	250mg/kg (250mg/kg)		American Review of Tuberculosis. Vol. 60, Pg. 62, 1949.
rabbit	LD50	skin	> 4gm/kg (4000mg/kg)		Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.
rat	LD50	intraperitoneal	196mg/kg (196mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 183, Pg. 36, 1970.
rat	LD50	oral	1gm/kg (1000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.
women	TDLo	oral	18mg/kg (18mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Acta Medica Scandinavica. Vol. 214, Pg. 215, 1983.
women	TDLo	oral	28mg/kg (28mg/kg)	BLOOD: AGRANULOCYTOSIS	British Medical Journal. Vol. 286, Pg. 1244, 1983.
women	TDLo	oral	112mg/kg/4W-I (112mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BLOOD: OXIDANT RELATED (GPD DEFICIENT) ANEMIA	Clinical and Experimental Dermatology. Vol. 20, Pg. 155, 1995.
women	TDLo	oral	300mg/kg/21W- (300mg/kg)	BLOOD: EOSINOPHILIA	Lancet. Vol. 343, Pg. 860, 1994.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn
Risk Statements: 22 
R22:Harmful if swallowed.
Safety Statements: 22 
S22:Do not breathe dust.
RIDADR: 3249
WGK Germany: 1
RTECS: BY8925000
HazardClass: 6.1(b)
PackingGroup of Dapsone (CAS NO.80-08-0): III

Standards and Recommendations：

 

Analytical Methods：