CAS No.:17431-55-9
Name: 7-Epiclindamycin hydrochloride
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 262mg/kg (262mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 727, 1966. | |
| mouse | LD50 | intravenous | 143mg/kg (143mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 727, 1966. | |
| mouse | LD50 | oral | 1479mg/kg (1479mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 773, 1969. |
| mouse | LD50 | subcutaneous | 656mg/kg (656mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 773, 1969. |
| rat | LD50 | intraperitoneal | 279mg/kg (279mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 773, 1969. |
| rat | LD50 | oral | 4022mg/kg (4022mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 773, 1969. |
| rat | LD50 | subcutaneous | 891mg/kg (891mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 773, 1969. |
Consensus Reports：
SAFETY PROFILE：
A poison by intraperitoneal and intravenous route. Moderately toxic by subcutaneous and ingestion routes. When heated to decomposition it emits toxic vapors of NOx, SOx, HCl, and Cl−.
Standards and Recommendations：
Analytical Methods：
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