CAS No.:141396-28-3
Name: Argatroban
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 475mg/kg (475mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: NORMOCYTIC ANEMIA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
| mouse | LD50 | intravenous | > 81mg/kg (81mg/kg) | BLOOD: HEMORRHAGE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
| mouse | LD50 | oral | > 15gm/kg (15000mg/kg) | BLOOD: HEMORRHAGE BLOOD: NORMOCYTIC ANEMIA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
| mouse | LD50 | subcutaneous | 3750mg/kg (3750mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: NORMOCYTIC ANEMIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
| rat | LD50 | intraperitoneal | 320mg/kg (320mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: NORMOCYTIC ANEMIA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
| rat | LD50 | intravenous | > 81mg/kg (81mg/kg) | BLOOD: HEMORRHAGE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
| rat | LD50 | oral | > 15gm/kg (15000mg/kg) | BLOOD: HEMORRHAGE BLOOD: NORMOCYTIC ANEMIA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
| rat | LD50 | subcutaneous | 620mg/kg (620mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: NORMOCYTIC ANEMIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl, |
Consensus Reports：
SAFETY PROFILE：
Standards and Recommendations：
Analytical Methods：
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