CAS No.:63521-15-3
Name: Cefazedone sodium salt
Details Introduction
TOXICITY DATA with REFERENCE:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 3gm/kg (3000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979. |
| mouse | LD50 | intramuscular | > 10gm/kg (10000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979. | |
| mouse | LD50 | intravenous | 6800mg/kg (6800mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979. |
| rabbit | LD50 | intravenous | 3200mg/kg (3200mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979. |
| rat | LD50 | intramuscular | > 10gm/kg (10000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979. | |
| rat | LD50 | intravenous | 4225mg/kg (4225mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979. |
Consensus Reports:
SAFETY PROFILE:
Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Used as an antibacterial agent. When heated to decomposition, it emits very toxic fumes of Cl−, NOx, Na2O, and SOx.
Standards and Recommendations:
Analytical Methods:
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