CAS No.:51762-05-1
Name: Cefroxadine
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 1gm/kg (1000mg/kg) | Drugs in Japan Vol. -, Pg. 689, 1995. | |
| mouse | LD50 | intraperitoneal | 7090mg/kg (7090mg/kg) | Journal of Antibiotics. Vol. 29, Pg. 653, 1976. | |
| mouse | LD50 | oral | > 13500mg/kg (13500mg/kg) |
behavioral: somnolence (general depressed activity) gastrointestinal: "hypermotility, diarrhea" |
Chemotherapy Vol. 28(Suppl, |
| mouse | LD50 | subcutaneous | 13500mg/kg (13500mg/kg) |
behavioral: somnolence (general depressed activity) gastrointestinal: "hypermotility, diarrhea" |
Chemotherapy Vol. 28(Suppl, |
| rabbit | LD50 | intraperitoneal | > 4gm/kg (4000mg/kg) |
kidney, ureter, and bladder: structural or functional changes in ureter kidney, ureter, and bladder: other changes |
Chemotherapy Vol. 28(Suppl, |
| rabbit | LD50 | oral | 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. APP-11, 1982. | |
| rat | LD50 | intraperitoneal | 6gm/kg (6000mg/kg) |
behavioral: ataxia gastrointestinal: "hypermotility, diarrhea" skin and appendages (skin): hair: other |
Chemotherapy Vol. 28(Suppl, |
| rat | LD50 | oral | > 22500mg/kg (22500mg/kg) |
behavioral: altered sleep time (including change in righting reflex) behavioral: somnolence (general depressed activity) gastrointestinal: "hypermotility, diarrhea" |
Chemotherapy Vol. 28(Suppl, |
| rat | LD50 | subcutaneous | > 15gm/kg (15000mg/kg) |
sense organs and special senses: mydriasis (pupillary dilation): eye behavioral: altered sleep time (including change in righting reflex) skin and appendages (skin): hair: other |
Chemotherapy Vol. 28(Suppl, |
Consensus Reports：
SAFETY PROFILE：
Mildly toxic by ingestion and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
Standards and Recommendations：
Analytical Methods：
Related Searches
Other Product
- -
- -
- -
- -
- -
- -
- -
- -
- -
- (4S,6R)-6-{2-[(2-hydroxy-ethyl)-(4-methoxy-benzenesulfonyl)-amino]-ethoxy}-4-isopropyl-5,6-dihydro-4H-pyran-2-carboxylic acid allyl ester
- [1,4'-Bipiperidine]-1'-carboxylic acid, 4-(1H-indol-7-yl)-, ethyl ester
- 1,3,5-Tris(4-acetamidophenyl)penta-1,5-dione
- 1,5-Bis(3-aminophenyl)-3-(4-N,N-di-methylaminophenyl)penta-1,5-dione
- 1,5-Bis(4-acetamidophenyl)-3-phenylpenta-1,5-dione
- 1,5-Bis(4-aminophenyl)-3-(4-acetamido-phenyl)penta-1,5-dione
- 1,5-Bis(4-aminophenyl)-3-phenylpenta-1,5-dione