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CAS No.:73-40-5

Name: Guanine

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intraperitoneal > 1gm/kg (1000mg/kg)   Annals of the New York Academy of Sciences. Vol. 60, Pg. 251, 1954.
mouse LD oral > 3333mg/kg (3333mg/kg)   French Medicament Patent Document. Vol. #2698M,


Consensus Reports:

 


SAFETY PROFILE:

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S37/39:Wear suitable gloves and eye/face protection.


Standards and Recommendations:

Guanine, is present in both DNA and RNA along with Adenine and cytosine, , whereas THYMINE is usually seen only in DNA, and URACIL only in RNA. Guanine has two tautomeric forms, the major keto form (see figures) and rare enol form. It binds to cytosine through three HYDROGEN bonds. In cytosine, the amino group acts as the HYDROGEN donor and the C-2 carbonyl and the N-3 amine as the HYDROGEN-bond acceptors. Guanine has a group at C-6 that acts as the HYDROGEN acceptor, while the group at N-1 and the amino group at C-2 act as the HYDROGEN donors.


Analytical Methods:

 


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