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Current position:Home > Products > Irinotecan hydrochloride trihydrate

CAS No.:136572-09-3

Name: Irinotecan hydrochloride trihydrate

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 40mg/kg (40mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
mouse LD50 intravenous 132mg/kg (132mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
mouse LD50 oral 1045mg/kg (1045mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
rat LD50 intravenous 83600ug/kg (83.6mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
rat LD50 oral 867mg/kg (867mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.


Consensus Reports:

 


SAFETY PROFILE:

A poison by intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx, HCl, and Cl.


Standards and Recommendations:

 


Analytical Methods:

 


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