CAS No.:136572-09-3
Name: Irinotecan hydrochloride trihydrate
Details Introduction
TOXICITY DATA with REFERENCE:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 40mg/kg (40mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
| mouse | LD50 | intravenous | 132mg/kg (132mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
| mouse | LD50 | oral | 1045mg/kg (1045mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
| rat | LD50 | intravenous | 83600ug/kg (83.6mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
| rat | LD50 | oral | 867mg/kg (867mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. |
Consensus Reports:
SAFETY PROFILE:
A poison by intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx, HCl, and Cl−.
Standards and Recommendations:
Analytical Methods:
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