CAS No.:84625-61-6

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 200mg/kg (200mg/kg)		Reviews of Infectious Diseases. Vol. 9(Suppl,
guinea pig	LD50	oral	> 160mg/kg (160mg/kg)		Reviews of Infectious Diseases. Vol. 9(Suppl,
man	TDLo	oral	240mg/kg/6W-I (240mg/kg)	LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" LIVER: LIVER FUNCTION TESTS IMPAIRED	Lancet. Vol. 340, Pg. 251, 1992.
mouse	LD50	intravenous	46400ug/kg (46.4mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 381, 1991.
mouse	LD50	oral	> 320mg/kg (320mg/kg)		Reviews of Infectious Diseases. Vol. 9(Suppl,
rat	LD50	intravenous	40mg/kg (40mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 381, 1991.
rat	LD50	oral	> 320mg/kg (320mg/kg)		Reviews of Infectious Diseases. Vol. 9(Suppl,
women	TDLo	oral	32mg/kg/8D-I (32mg/kg)	SKIN AND APPENDAGES (SKIN): HAIR: OTHER	British Medical Journal. Vol. 293, Pg. 822, 1986.
women	TDLo	oral	140mg/kg/5W-I (140mg/kg)	LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" LIVER: LIVER FUNCTION TESTS IMPAIRED SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Lancet. Vol. 340, Pg. 251, 1992.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-36/38-22 
R36/37/38: Irritating to eyes, respiratory system and skin. 
R36/38: Irritating to eyes and skin. 
R22: Harmful if swallowed.
Safety Statements: 22-26-36 
S22: Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS Itraconazole (CAS NO.84625-61-6): XZ5481000

Standards and Recommendations：

 

Analytical Methods：