CAS No.:32891-29-5
Name: Mazaticol hydrochloride
Details Introduction
TOXICITY DATA with REFERENCE：
The toxicity of Mazaticol hydrochloride (CAS NO.32891-29-5):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 126mg/kg (126mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA |
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 2448, 1972. |
| mouse | LD50 | intravenous | 20200ug/kg (20.2mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA |
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 2448, 1972. |
| mouse | LD50 | oral | 263mg/kg (263mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 67, Pg. 387, 1971. |
| mouse | LD50 | subcutaneous | 341mg/kg (341mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 2448, 1972. |
| rat | LD50 | intraperitoneal | 104mg/kg (104mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA |
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 2448, 1972. |
| rat | LD50 | intravenous | 12900ug/kg (12.9mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 67, Pg. 387, 1971. |
| rat | LD50 | oral | 1182mg/kg (1182mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 2448, 1972. |
| rat | LD50 | subcutaneous | > 1099mg/kg (1099mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 2448, 1972. |
Consensus Reports：
SAFETY PROFILE：
The safety information of Mazaticol hydrochloride (CAS NO.32891-29-5):
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx, NOx, and HCl. See also ESTERS.
Standards and Recommendations：
Analytical Methods：
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