CAS No.:2154-02-1

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	295mg/kg (295mg/kg)		Medicinal Chemistry: A Series of Monographs. Vol. 5, Pg. 318, 1965.
mouse	LD50	intraperitoneal	70mg/kg (70mg/kg)		Medicinal Chemistry: A Series of Monographs. Vol. 5, Pg. 318, 1965.
mouse	LD50	intravenous	25mg/kg (25mg/kg)		Toxicology and Applied Pharmacology. Vol. 6, Pg. 334, 1964.
mouse	LD50	oral	180mg/kg (180mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Experientia. Vol. 18, Pg. 446, 1962.
mouse	LD50	subcutaneous	180mg/kg (180mg/kg)		"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 966, 1989.
rabbit	LD50	intravenous	30mg/kg (30mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Experientia. Vol. 18, Pg. 446, 1962.
rat	LD50	intraperitoneal	100mg/kg (100mg/kg)		Medicinal Chemistry: A Series of Monographs. Vol. 5, Pg. 318, 1965.
rat	LD50	oral	400mg/kg (400mg/kg)		Medicinal Chemistry: A Series of Monographs. Vol. 5, Pg. 318, 1965.
rat	LD50	subcutaneous	400mg/kg (400mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Experientia. Vol. 18, Pg. 446, 1962.

Consensus Reports：

 

SAFETY PROFILE：

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits very toxic fumes of HCl and NO_x.

Standards and Recommendations：

 

Analytical Methods：