CAS No.:2021-21-8
Name: N-Methyl-4-cyclohexene-1,2-dicarb-oximide
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | oral | 2500ug/kg (2.5mg/kg) | Experimental Animals. Jikken Dobutso Iho. Vol. 21, Pg. 88, 1972. | |
| cat | LD50 | skin | 4mg/kg (4mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969. |
| chicken | LDLo | oral | 50mg/kg (50mg/kg) | Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. | |
| dog | LD50 | oral | 2mg/kg (2mg/kg) | Experimental Animals. Jikken Dobutso Iho. Vol. 21, Pg. 88, 1972. | |
| dog | LD50 | skin | 2750ug/kg (2.75mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969. |
| dog | LDLo | intraperitoneal | 2mg/kg (2mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
| guinea pig | LD50 | oral | 500ug/kg (0.5mg/kg) | Experimental Animals. Jikken Dobutso Iho. Vol. 21, Pg. 88, 1972. | |
| guinea pig | LD50 | skin | 5mg/kg (5mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
| guinea pig | LDLo | subcutaneous | 1mg/kg (1mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
| monkey | LD50 | oral | 300mg/kg (300mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
| monkey | LDLo | intraperitoneal | 100mg/kg (100mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
| monkey | LDLo | skin | 800mg/kg (800mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
| monkey | LDLo | subcutaneous | 150mg/kg (150mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
| mouse | LD50 | intraperitoneal | 164mg/kg (164mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
| mouse | LD50 | oral | 200mg/kg (200mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 463, 1970. | |
| mouse | LD50 | skin | 370mg/kg (370mg/kg) | Experimental Animals. Jikken Dobutso Iho. Vol. 21, Pg. 88, 1972. | |
| mouse | LD50 | subcutaneous | 216mg/kg (216mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
| rabbit | LD50 | oral | 1500ug/kg (1.5mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Experimental Animals. Jikken Dobutso Iho. Vol. 21, Pg. 88, 1972. |
| rabbit | LD50 | skin | 1750ug/kg (1.75mg/kg) | Experimental Animals. Jikken Dobutso Iho. Vol. 21, Pg. 88, 1972. | |
| rabbit | LDLo | intravenous | 5mg/kg (5mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
| rat | LD50 | oral | 67mg/kg (67mg/kg) | Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 9, Pg. 563, 1967. | |
| rat | LD50 | skin | 213mg/kg (213mg/kg) | World Review of Pest Control. Vol. 9, Pg. 119, 1970. | |
| rat | LD50 | subcutaneous | 41mg/kg (41mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Toxicology and Applied Pharmacology. Vol. 12, Pg. 536, 1968. |
Consensus Reports：
SAFETY PROFILE：
An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Standards and Recommendations：
Analytical Methods：
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