CAS No.:62-75-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LCLo	inhalation	16ppm/4H (16ppm)	BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: NAUSEA OR VOMITING	AMA Archives of Industrial Health. Vol. 12, Pg. 617, 1955.
dog	LDLo	oral	20mg/kg (20mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: HEMORRHAGE	British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
guinea pig	LD50	intraperitoneal	13700ug/kg (13.7mg/kg)		Carcinogenesis Vol. 5, Pg. 533, 1984.
guinea pig	LDLo	oral	25mg/kg (25mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI BLOOD: THROMBOCYTOPENIA	"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 183, 1999.
guinea pig	LDLo	unreported	25mg/kg (25mg/kg)	BLOOD: HEMORRHAGE	British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
hamster	LD50	oral	28mg/kg (28mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH LIVER: FATTY LIVER DEGERATION LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"	Journal of the National Cancer Institute. Vol. 33, Pg. 341, 1964.
hamster	LD50	subcutaneous	17700ug/kg (17.7mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES BLOOD: OTHER CHANGES	British Journal of Cancer. Vol. 33, Pg. 411, 1976.
hamster	LDLo	intraperitoneal	30mg/kg (30mg/kg)		Carcinogenesis Vol. 1, Pg. 91, 1980.
mammal (species unspecified)	LD50	subcutaneous	10mg/kg (10mg/kg)		Acta Veterinaria Scandinavica. Vol. 22, Pg. 501, 1981.
mammal (species unspecified)	LD50	subcutaneous	10mg/kg (10mg/kg)		Acta Veterinaria Scandinavica. Vol. 22, Pg. 501, 1981.
mammal (species unspecified)	LD50	subcutaneous	10mg/kg (10mg/kg)	LIVER: OTHER CHANGES	Acta Veterinaria Scandinavica. Vol. 22, Pg. 501, 1981.
mouse	LC50	inhalation	57ppm/4H (57ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE	AMA Archives of Industrial Health. Vol. 12, Pg. 617, 1955.
mouse	LD50	intraperitoneal	19mg/kg (19mg/kg)		Experientia. Vol. 32, Pg. 495, 1976.
mouse	LDLo	unreported	20mg/kg (20mg/kg)	LIVER: OTHER CHANGES	British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
rabbit	LDLo	oral	10mg/kg (10mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI BLOOD: THROMBOCYTOPENIA	"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 183, 1999.
rabbit	LDLo	unreported	10mg/kg (10mg/kg)	LIVER: OTHER CHANGES	British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
rat	LC50	inhalation	78ppm/4H (78ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE	AMA Archives of Industrial Health. Vol. 12, Pg. 617, 1955.
rat	LD50	intraperitoneal	26500ug/kg (26.5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER	British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
rat	LD50	oral	37mg/kg (37mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(8), Pg. 81, 1985.
rat	LD50	subcutaneous	15mg/kg (15mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI BLOOD: THROMBOCYTOPENIA	"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 183, 1999.
rat	LD50	unreported	36mg/kg (36mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980.
rat	LDLo	intravenous	40mg/kg (40mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER	British Journal of Industrial Medicine. Vol. 11, Pg. 167, 1954.
women	LDLo	oral	20mg/kg/2.5Y (20mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: NAUSEA OR VOMITING	Oncology. Vol. 37, Pg. 273, 1980.

Consensus Reports：

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 125.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 ,1972,p. 95.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 125.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 ,1972,p. 95.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program. Community Right-To-Know List. EPA Extremely Hazardous Substances List.

SAFETY PROFILE：

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. Human poison by ingestion. Experimental poison by ingestion, inhalation, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: ulceration or bleeding from small intestine, nausea or vomiting, and fever. Experimental reproductive effects. Human mutation data reported. Has caused fatal liver disease in humans. When heated to decomposition it emits toxic fumes of NO_x. See also NITROSAMINES.
Analytical Methods: 
For occupational chemical analysis use OSHA: #27.
When heated to decomposition, n-Nitrosodimethylamine emits toxic fumes of nitrogen oxides. Avoid exposure to ultraviolet light.
Safety Information of  n-Nitrosodimethylamine (62-75-9):
Hazard Codes: T+,N,F
Risk Statements: 45-25-26-48/25-51/53-39/23/24/25-23/24/25-11 
11:  Highly Flammable 
23:  Toxic by inhalation 
24:  Toxic in contact with skin 
25:  Toxic if swallowed 
26:  Very Toxic by inhalation 
39:  Danger of very serious irreversible effects
45:  May cause cancer 
48:  Danger of serious damage to health by prolonged exposure 
51:  Toxic to aquatic organisms
53:  May cause long-term adverse effects in the aquatic environment
Safety Statements: 53-45-61-36/37
36:  Wear suitable protective clothing 
37:  Wear suitable gloves 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53:  Avoid exposure - obtain special instruction before use 
61:  Avoid release to the environment. Refer to special instructions safety data sheet 

Standards and Recommendations：

OSHA PEL: Cancer Suspect Agent
ACGIH TLV: Animal Carcinogen
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen

Analytical Methods：

For occupational chemical analysis use OSHA: #27.