CAS No.:63951-12-2
Name: N-Phenyl-n-ethyl-n',n'-diethyl ethylenediamine hydrochloride
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | intravenous | 30mg/kg (30mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Annales de l'Institut Pasteur Vol. 63, Pg. 485, 1939. |
| guinea pig | LDLo | subcutaneous | 250mg/kg (250mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Annales de l'Institut Pasteur Vol. 63, Pg. 485, 1939. |
| mouse | LDLo | intravenous | 30mg/kg (30mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Annales de l'Institut Pasteur Vol. 63, Pg. 485, 1939. |
| mouse | LDLo | subcutaneous | 400mg/kg (400mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Annales de l'Institut Pasteur Vol. 63, Pg. 485, 1939. |
| rabbit | LDLo | intravenous | 25mg/kg (25mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: EXCITEMENT |
Annales de l'Institut Pasteur Vol. 63, Pg. 485, 1939. |
| rabbit | LDLo | subcutaneous | 250mg/kg (250mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Annales de l'Institut Pasteur Vol. 63, Pg. 485, 1939. |
| rat | LD50 | intraperitoneal | 142mg/kg (142mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 83, Pg. 120, 1945. | |
| rat | LD50 | subcutaneous | 750mg/kg (750mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 68, Pg. 339, 1942. |
Consensus Reports：
SAFETY PROFILE：
A poison by intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic vapors of NOx and HCl.
Standards and Recommendations：
Analytical Methods：
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