CAS No.:2062-78-4

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	32mg/kg (32mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
dog	LD50	oral	40mg/kg (40mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
guinea pig	LD50	oral	189mg/kg (189mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
man	TDLo	oral	7714ug/kg/15W (7.714mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FLUID INTAKE KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Journal of Clinical Pyschopharmacology. Vol. 12, Pg. 140, 1992.
mouse	LD50	intraperitoneal	1070mg/kg (1070mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse	LD50	intravenous	14mg/kg (14mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 288, 1972.
mouse	LD50	oral	228mg/kg (228mg/kg)	BEHAVIORAL: ATAXIA	Collection of Czechoslovak Chemical Communications. Vol. 42, Pg. 1179, 1977.
mouse	LD50	subcutaneous	> 16gm/kg (16000mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE	Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 629, 1972.
rabbit	LD50	intravenous	22mg/kg (22mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rabbit	LD50	oral	40mg/kg (40mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat	LD50	intraperitoneal	350mg/kg (350mg/kg)		Drugs in Japan Vol. 6, Pg. 639, 1982.
rat	LD50	intravenous	90mg/kg (90mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat	LD50	oral	1100mg/kg (1100mg/kg)		Drugs in Japan Vol. 6, Pg. 639, 1982.
rat	LD50	subcutaneous	> 11gm/kg (11000mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE	Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 629, 1972.

Consensus Reports：

 

SAFETY PROFILE：

Poison by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and F⁻.
Hazard Codes Xn
Risk Statements 22
R22:Harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
RIDADR 3249
WGK Germany 3
RTECS DE1750000
HazardClass 6.1(b)
PackingGroup III

Standards and Recommendations：

 

Analytical Methods：