CAS No.:51-06-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intravenous	170mg/kg (170mg/kg)		Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 833, 1980.
dog	LDLo	oral	2210mg/kg (2210mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 253, 1972.
guinea pig	LD50	intravenous	280mg/kg (280mg/kg)		Farmaco, Edizione Scientifica. Vol. 12, Pg. 77, 1957.
human	TDLo	oral	2280mg/kg/22W (2280mg/kg)	MUSCULOSKELETAL: JOINTS	British Heart Journal. Vol. 34, Pg. 284, 1972.
man	TDLo	intravenous	583mg/kg/12D- (583mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	American Heart Journal. Vol. 109, Pg. 375, 1985.
man	TDLo	oral	29mg/kg (29mg/kg)	BEHAVIORAL: TREMOR	American Journal of Cardiology. Vol. 57, Pg. 340, 1986.
man	TDLo	oral	8579mg/kg/43W (8579mg/kg)	LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS	American Journal of Medicine. Vol. 76, Pg. 146, 1984.
man	TDLo	unreported	31gm/kg/3Y-I (31000mg/kg)	VASCULAR: STRICTIRA; CJAMGES OM VESSE;S SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Clinical and Experimental Rheumatology. Vol. 4, Pg. 290, 1986.
mouse	LD50	intraperitoneal	178mg/kg (178mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Polish Journal of Pharmacology and Pharmacy. Vol. 37, Pg. 551, 1985.
mouse	LD50	intravenous	49mg/kg (49mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Polish Journal of Pharmacology and Pharmacy. Vol. 37, Pg. 551, 1985.
mouse	LD50	oral	525mg/kg (525mg/kg)		Collection of Czechoslovak Chemical Communications. Vol. 42, Pg. 3628, 1977.
mouse	LD50	subcutaneous	720mg/kg (720mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Polish Journal of Pharmacology and Pharmacy. Vol. 37, Pg. 551, 1985.
rabbit	LD50	intravenous	125mg/kg (125mg/kg)		Polish Journal of Pharmacology and Pharmacy. Vol. 32, Pg. 833, 1980.
rat	LD50	intravenous	110mg/kg (110mg/kg)		Russian Pharmacology and Toxicology Vol. 33, Pg. 292, 1970.
rat	LD50	oral	1950mg/kg (1950mg/kg)		Collection of Czechoslovak Chemical Communications. Vol. 42, Pg. 3628, 1977.
rat	LD50	unreported	110mg/kg (110mg/kg)		Farmakologiya i Toksikologiya Vol. 54(3), Pg. 32, 1991.
women	TDLo	oral	1120mg/kg/4W- (1120mg/kg)	BEHAVIORAL: WAKEFULNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TOXIC PSYCHOSIS	American Journal of Psychiatry. Vol. 145, Pg. 129, 1988.
women	TDLo	oral	1826mg/kg/13W (1826mg/kg)	CARDIAC: OTHER CHANGES	American Heart Journal. Vol. 83, Pg. 798, 1972.

Consensus Reports：

 

SAFETY PROFILE：

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by ingestion: cardiac abnormalities, joint effects, cough, tremors, dyspnea, and other lung effects. When heated to decomposition it emits toxic fumes of NO_x.

Standards and Recommendations：

 

Analytical Methods：