CAS No.:60-93-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	intravenous	630mg/kg/1W-I (630mg/kg)	SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE" SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE GASTROINTESTINAL: NAUSEA OR VOMITING	Japanese Journal of Ophthalmology. Vol. 28, Pg. 409, 1984.
guinea pig	LD50	intravenous	57mg/kg (57mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
guinea pig	LDLo	subcutaneous	199mg/kg (199mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 32, Pg. 595, 1935.
mouse	LD50	intravenous	86mg/kg (86mg/kg)		Biochemical Journal. Vol. 28, Pg. 426, 1934.
mouse	LD50	oral	660mg/kg (660mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rabbit	LD50	intravenous	35mg/kg (35mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rabbit	LD50	oral	641mg/kg (641mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rat	LD50	intravenous	78mg/kg (78mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rat	LD50	oral	1392mg/kg (1392mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.

Consensus Reports：

 

SAFETY PROFILE：

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and HCl. Safety Information of Quinine dihydrochloride (CAS NO.60-93-5) is:
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin 
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36: Wear suitable protective clothing   
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

Standards and Recommendations：

 

Analytical Methods：