CAS No.:57-24-9

TOXICITY DATA with REFERENCE：The  toxicity of  STRYCHNINE(57-24-9):

1.		ims-rat TDLo:500 µg/kg (5D preg):REP		PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 100 (1959),555.
2.		orl-hmn LDLo:30 mg/kg		PCOC**    Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc. (Topeka, KS.: )1966,1073.
3.		orl-man LDLo:30 mg/kg		PEMNDP    Pesticide Manual. 9 (1991),771.
4.		orl-man LDLo:5143 mg/kg		JTCTDW    Journal of Toxicology, Clinical Toxicology. 30 (1992),269.
5.		orl-rat LD50:2350 µg/kg		JAPMA8    Journal of the American Pharmaceutical Association, Scientific Edition. 31 (1942),113.
6.		ipr-rat LD50:1100 µg/kg		JPETAB    Journal of Pharmacology and Experimental Therapeutics. 58 (1936),239.
7.		scu-rat LD50:1200 µg/kg		RPTOAN    Russian Pharmacology and Toxicology. Translation of FATOAO. 31 (1968),260.
8.		ivn-rat LD50:582 µg/kg		CHHTAT    Zhonghua Yixue Zazhi. Chinese Medical Journal. 54 (1974),234.
9.		orl-mus LD50:2 mg/kg		IJEBA6    Indian Journal of Experimental Biology. 19 (1981),1075.
10.		ipr-mus LD50:980 µ

Consensus Reports：Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.
SAFETY PROFILE：
Human poison by ingestion. Experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. An allergen. Lethal dose to man: 30–60 mg/kg. If ingested, the time of action depends upon the condition of the stomach, whether empty or full, and the nature of the food present. If taken by subcutaneous injection, the place of administration of the injection will affect the time of action. The first symptoms are a feeling of uneasiness with a heightened reflex of irritability, followed by muscular twitching in some parts of the body. With larger doses, this is followed by a sense of impending suffocation. Convulsive movements begin that have the effect of mechanically causing the patient to cry out or to shriek; then follow the characteristic spasms, which set in with violence. These are at first clonic and then tonic. There are successive attacks of spasms. With each successive attack, the symptoms become more violent, eventually resulting in death. A rodenticide. When heated to decomposition it emits toxic fumes of NO_x.
Standards and Recommendations：The standards of  STRYCHNINE:
OSHA PEL: TWA 0.15 mg/m³
ACGIH TLV: TWA 0.15 mg/m³
DFG MAK: 0.15 mg/m³
DOT Classification:  6.1; Label: Poison
Analytical Methods：The analyticalmethods of  STRYCHNINE(57-24-9): For occupational chemical analysis use NIOSH: Strychnine, 5016.