CAS No.:509-67-1
Name: TETRAHYDRO-1,4-OXAZINYLMETHYLCODEINE
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 400mg/kg (400mg/kg) | Therapie. Vol. 7, Pg. 21, 1952. | |
| mouse | LD50 | intravenous | 230mg/kg (230mg/kg) | Therapie. Vol. 7, Pg. 21, 1952. | |
| mouse | LD50 | oral | 1gm/kg (1000mg/kg) | Cesko-Slovenska Farmacie. Vol. 12, Pg. 89, 1963. | |
| mouse | LD50 | subcutaneous | 540mg/kg (540mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT |
Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 325, 1958. |
| rabbit | LD50 | intravenous | 300mg/kg (300mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT |
Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 325, 1958. |
Consensus Reports：
SAFETY PROFILE：
Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx. Used as an antitussive agent. See also CODEINE.
Standards and Recommendations：
Analytical Methods：
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