CAS No.:850-57-7

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intraarterial	80mg/kg (80mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig	LDLo	intravenous	55mg/kg (55mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
mouse	LD50	intraperitoneal	25mg/kg (25mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: IRRITABILITY	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 61, Pg. 396, 1965.
mouse	LD50	subcutaneous	31mg/kg (31mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: IRRITABILITY	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 61, Pg. 396, 1965.
rabbit	LD50	intravenous	3351ug/kg (3.351mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 132, Pg. 255, 1961.
rabbit	LDLo	subcutaneous	9741ug/kg (9.741mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 66, Pg. 182, 1939.

Consensus Reports：

 

SAFETY PROFILE：

Poison by intravenous, subcutaneous, and intraperitoneal routes. An experimental teratogen. When Thebaine hydrochloride (CAS NO.850-57-7) is heated to decomposition, it emits toxic fumes of NO_x and HCl.

Standards and Recommendations：

 

Analytical Methods：