CAS No.:101-02-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intraperitoneal	100mg/kg (100mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	National Technical Information Service. Vol. OTS0570901,
cat	LDLo	subcutaneous	300mg/kg (300mg/kg)	BEHAVIORAL: ATAXIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 78, 1933.
chicken	LDLo	intravenous	50mg/kg (50mg/kg)	AUTONOMIC NERVOUS SYSTEM: GAGLION BLOCK	Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 44, Pg. 118, 1989.
chicken	LDLo	oral	250mg/kg (250mg/kg)	BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0532280,
chicken	LDLo	subcutaneous	375mg/kg (375mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0532280,
mammal (species unspecified)	LD50	intraperitoneal	250mg/kg (250mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES CARDIAC: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 5, Pg. 311, 1952.
mouse	LD50	intraperitoneal	266mg/kg (266mg/kg)		Agricultural and Biological Chemistry. Vol. 31, Pg. 1288, 1967.
mouse	LD50	oral	1080mg/kg (1080mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(12), Pg. 53, 1987.
mouse	LD50	unreported	1360mg/kg (1360mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 21(9), Pg. 55, 1977.
rabbit	LDLo	skin	5gm/kg (5000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	National Technical Information Service. Vol. OTS0532280,
rat	LC	inhalation	> 6700mg/m3/1H (6700mg/m3)		National Technical Information Service. Vol. OTS0532280,
rat	LD50	intraperitoneal	250mg/kg (250mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1117, 1986.
rat	LD50	oral	444mg/kg (444mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(12), Pg. 13, 1981.
rat	LD50	unreported	1490mg/kg (1490mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 21(9), Pg. 55, 1977.
rat	LDLo	subcutaneous	2gm/kg (2000mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE WEAKNESS	Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 78, 1933.

Consensus Reports：

Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. An experimental eye and severe human skin irritant. Combustible when exposed to heat or flame. To fight fire, use CO₂, mist, dry chemical. When heated to decomposition, it emits toxic fumes of PO_x. See also Phenol.
Hazard Codes: XnN,Xi
Risk Statements: 36/38-50/53
R36/38:Irritating to eyes and skin. 
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 28-60-61-28A
S28:After contact with skin, wash immediately with plenty of soap-suds. 
S60:This material and its container must be disposed of as hazardous waste. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets. 
S28:After contact with skin, wash immediately with plenty of soap-suds.
RIDADR: UN 3077 9/PG 3
WGK Germany: 2
RTECS: TH1575000
HazardClass: 9
PackingGroup: III
HS Code: 29209085

Standards and Recommendations：

 

Analytical Methods：