CAS No.:2001-95-8

TOXICITY DATA with REFERENCE：

  Valinomycin  (2001-95-8)  is highly toxic orally.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	390ug/kg (0.39mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	intravenous	180ug/kg (0.18mg/kg)		Cancer Research. Vol. 46, Pg. 5518, 1986.
mouse	LD50	oral	2500ug/kg (2.5mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 325, 1978.
mouse	LD50	subcutaneous	4140ug/kg (4.14mg/kg)		Antibiotics and Chemotherapy Vol. 12, Pg. 482, 1962.
rabbit	LD50	skin	5mg/kg (5mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Drug and Chemical Toxicology. Vol. 8, Pg. 451, 1985.
rat	LD50	intraperitoneal	800ug/kg (0.8mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Drug and Chemical Toxicology. Vol. 8, Pg. 451, 1985.
rat	LD50	oral	4mg/kg (4mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Drug and Chemical Toxicology. Vol. 8, Pg. 451, 1985.

Consensus Reports：

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Poison by ingestion, skin contact, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
When heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides.
Safety Information of Valinomycin (2001-95-8):
Hazard Codes: Xn,T
Risk Statements: 27/28-36/37/38 
27:  Very Toxic in contact with skin 
28:  Very Toxic if swallowed 
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
Safety Statements: 36-45-36/37-28-37/39-26
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
28:  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36:  Wear suitable protective clothing  
37:  Wear suitable gloves  
39:  Wear eye/face protection 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Standards and Recommendations：

 

Analytical Methods：