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Current position:Home > Products > 1-(p-CHLOROPHENYL)-5-ISOPROPYLBI GUANIDE HYDROCHLORIDE

CAS No.:637-32-1

Name: 1-(p-CHLOROPHENYL)-5-ISOPROPYLBI GUANIDE HYDROCHLORIDE

Details Introduction

TOXICITY DATA with REFERENCE:

1.    

orl-rat LD50:58 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
2.    

ivn-rat LD50:33 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
3.    

orl-mus LD50:27 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
4.    

ivn-mus LD50:23 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
5.    

orl-rbt LD50:172 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 2 (1947),181.
6.    

ivn-rbt LD50:44,850 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
7.    

ivn-gpg LD50:39,510 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
8.    

orl-ckn LD50:400 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 2 (1947),181.

Consensus Reports:

 


SAFETY PROFILE:

Poison by ingestion and intravenous routes. Experimental reproductive effects. An antimalarial drug. When heated to decomposition it emits very toxic fumes of Cl− and NOx.Safety information of Proguanil hydrochloride (CAS NO.637-32-1):
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III


Standards and Recommendations:

 


Analytical Methods:

 


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