CAS No.:107007-99-8

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	3mg/kg (3mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING	Yakkyoku. Pharmacy. Vol. 43, Pg. 589, 1992.
dog	LDLo	oral	15mg/kg (15mg/kg)	BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 2697, 1995.
mouse	LD50	intravenous	17mg/kg (17mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990.
mouse	LD50	oral	350mg/kg (350mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
rat	LD50	intravenous	14mg/kg (14mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990.
rat	LD50	oral	350mg/kg (350mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn,Xi
Risk Statements: 22-62-37/38-36/37/38-36 
R22:Harmful if swallowed. 
R62:Risk of impaired fertility. 
R37/38:Irritating to respiratory system and skin. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R36:Irritating to eyes.
Safety Statements: 26-36-37 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S37:Wear suitable gloves.
RTECS: NK7882200

Standards and Recommendations：

 

Analytical Methods：