CAS No.:93-14-1

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	335mg/kg (335mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 688, 1958.
mouse	LD50	intramuscular	2210mg/kg (2210mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 429, 1974.
mouse	LD50	intraperitoneal	495mg/kg (495mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 398, 1972.
mouse	LD50	intravenous	400mg/kg (400mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 429, 1974.
mouse	LD50	oral	690mg/kg (690mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 398, 1972.
mouse	LD50	subcutaneous	800mg/kg (800mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 1355, 1965.
rabbit	LD50	oral	2553mg/kg (2553mg/kg)		Applied Therapeutics. Vol. 9, Pg. 55, 1967.
rat	LD50	intramuscular	4gm/kg (4000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 429, 1974.
rat	LD50	intraperitoneal	1gm/kg (1000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 191, Pg. 147, 1971.
rat	LD50	intravenous	360mg/kg (360mg/kg)	BEHAVIORAL: ATAXIA KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Proceedings of the Society for Experimental Biology and Medicine. Vol. 85, Pg. 323, 1954.
rat	LD50	oral	1510mg/kg (1510mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Pharmacological Research Communications. Vol. 1, Pg. 413, 1969.
rat	LD50	subcutaneous	2550mg/kg (2550mg/kg)		Drugs in Japan Vol. 6, Pg. 210, 1982.

Consensus Reports：

 

SAFETY PROFILE：

Safety Information about Guaifenesin (CAS NO.93-14-1):
Hazard Codes: Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 1
RTECS: TY8400000
Hazard Note: Harmful
Guaifenesin has side effect if consumption in above-normal quantities.May be cause nausea, vomiting, and the formation of kidney stones of URIC ACID.

Standards and Recommendations：

 

Analytical Methods：