CAS No.:1951-5-8
Name: Procaine HCL
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 10mg/kg (10mg/kg) |
Behavioral: convulsions or effect
on seizure threshold Cardiac: change in rate |
Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 385, 1916. |
| dog | LD50 | intravenous | 63mg/kg (63mg/kg) |
Cardiac: other changes
Vascular: bp lowering not characterized in autonomic section lungs, thorax, or Respiration: respiratory depression |
Journal of Dental Research. Vol. 20, Pg. 425, 1941. |
| dog | LDLo | intracrebral | 11mg/kg (11mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 137, 1959. | |
| guinea pig | LD50 | intravenous | 51mg/kg (51mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. | |
| guinea pig | LD50 | subcutaneous | 407mg/kg (407mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948. | |
| mammal (species unspecified) | LD50 | subcutaneous | 630mg/kg (630mg/kg) | Ceska a Slovenska Farmacie. Vol. 44, Pg. 210, 1995. | |
| man | TDLo | multiple routes | 2286mg/kg/8D- (2286mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | American Journal of Kidney Diseases. Vol. 7, Pg. 502, 1986. |
| mouse | LD50 | intracrebral | 33mg/kg (33mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63(3), Pg. 93S, 1967. | |
| mouse | LD50 | intramuscular | 500mg/kg (500mg/kg) | Therapie. Vol. 9, Pg. 332, 1954. | |
| mouse | LD50 | intraperitoneal | 165mg/kg (165mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 793, 1976. | |
| mouse | LD50 | intravenous | 33mg/kg (33mg/kg) | Anesthesia Progress. Vol. 36, Pg. 79, 1989. | |
| mouse | LD50 | oral | 175mg/kg (175mg/kg) | Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951. | |
| mouse | LD50 | parenteral | 192mg/kg (192mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT |
Antibiotics and Chemotherapy Vol. 4, Pg. 633, 1954. |
| mouse | LD50 | subcutaneous | 339mg/kg (339mg/kg) | Bollettino Chimico Farmaceutico. Vol. 107, Pg. 310, 1968. | |
| rabbit | LD50 | intracrebral | 4800ug/kg (4.8mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA |
Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 137, 1959. |
| rabbit | LD50 | intravenous | 43mg/kg (43mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979. | |
| rabbit | LD50 | subcutaneous | 687mg/kg (687mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948. | |
| rabbit | LD50 | unreported | 41mg/kg (41mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1957, 1974. |
|
| rabbit | LDLo | intraspinal | 15504ug/kg (15.504mg/kg) | PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC | Anesthesiology. Vol. 1, Pg. 305, 1940. |
| rat | LD50 | intraperitoneal | 160mg/kg (160mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979. | |
| rat | LD50 | intravenous | 38mg/kg (38mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Anesthesiology. Vol. 3, Pg. 398, 1942. |
| rat | LD50 | oral | 200mg/kg (200mg/kg) | Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951. | |
| rat | LD50 | subcutaneous | 597mg/kg (597mg/kg) | Pharmaceutical Archives. Vol. 11, Pg. 81, 1940. | |
| rat | LD50 | unreported | 150mg/kg (150mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1012, 1967. |
Consensus Reports：
SAFETY PROFILE：
Safety Information of Procaine HCL (1951-5-8):
Hazard Codes: T
T: Toxic .gif){kind=small}
Risk Statements: 25-43-36/37/38-23/24/25
25: Toxic if swallowed
43: May cause sensitization by skin contact
36/37/38: Irritating to eyes, respiratory system and skin
23/24/25: Toxic by inhalation, in contact with skin and if swallowed
Safety Statements: 36/37/39-45-37/39-26
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
37/39: Wear suitable gloves and eye/face protection
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DG2275000
HazardClass: 6.1
PackingGroup: III
Standards and Recommendations：
Analytical Methods：
Related Searches
Other Product
- -
- -
- -
- -
- -
- -
- -
- -
- -
- (4S,6R)-6-{2-[(2-hydroxy-ethyl)-(4-methoxy-benzenesulfonyl)-amino]-ethoxy}-4-isopropyl-5,6-dihydro-4H-pyran-2-carboxylic acid allyl ester
- [1,4'-Bipiperidine]-1'-carboxylic acid, 4-(1H-indol-7-yl)-, ethyl ester
- 1,3,5-Tris(4-acetamidophenyl)penta-1,5-dione
- 1,5-Bis(3-aminophenyl)-3-(4-N,N-di-methylaminophenyl)penta-1,5-dione
- 1,5-Bis(4-acetamidophenyl)-3-phenylpenta-1,5-dione
- 1,5-Bis(4-aminophenyl)-3-(4-acetamido-phenyl)penta-1,5-dione
- 1,5-Bis(4-aminophenyl)-3-phenylpenta-1,5-dione