CAS No.:106-50-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	100mg/kg (100mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat	LDLo	oral	100mg/kg (100mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.
dog	LDLo	intravenous	17mg/kg (17mg/kg)		Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.
dog	LDLo	subcutaneous	100mg/kg (100mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING	U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 40, 1941.
guinea pig	LD50	oral	145mg/kg (145mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(7), Pg. 62, 1988.
guinea pig	LD50	unreported	145mg/kg (145mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 46, 1987.
man	TDLo	oral	71mg/kg (71mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Human Toxicology. Vol. 8, Pg. 345, 1989.
mouse	LD50	intraperitoneal	50mg/kg (50mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	unreported	331mg/kg (331mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(6), Pg. 78, 1985.
mouse	LDLo	oral	100mg/kg (100mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 23(5), Pg. 14, 1958.
mouse	LDLo	subcutaneous	140mg/kg (140mg/kg)		Journal of the Society of Cosmetic Chemists. Vol. 12, Pg. 500, 1961.
quail	LD50	oral	100mg/kg (100mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rabbit	LDLo	intraperitoneal	150mg/kg (150mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.
rabbit	LDLo	intravenous	300mg/kg (300mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Archives of Internal Medicine. Vol. 36, Pg. 724, 1925.
rabbit	LDLo	oral	250mg/kg (250mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.
rabbit	LDLo	skin	5gm/kg (5000mg/kg)		Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.
rabbit	LDLo	subcutaneous	200mg/kg (200mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.
rat	LC50	inhalation	920mg/m3/4H (920mg/m3)	BEHAVIORAL: GENERAL ANESTHETIC KIDNEY, URETER, AND BLADDER: HEMATURIA GASTROINTESTINAL: NAUSEA OR VOMITING	National Technical Information Service. Vol. OTS0530403,
rat	LD50	intraperitoneal	37mg/kg (37mg/kg)		Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.
rat	LD50	oral	80mg/kg (80mg/kg)		Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.
rat	LD50	unreported	133mg/kg (133mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 46, 1987.
rat	LDLo	intravenous	50mg/kg (50mg/kg)		Bulletin de la Societe Royale des Sciences de Liege. Vol. 41, Pg. 302, 1972.
rat	LDLo	subcutaneous	170mg/kg (170mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

Consensus Reports：

 

SAFETY PROFILE：

When tested by the United States Environmental Protection Agency, the EPA reported that in rats and mice chronically exposed to PPD in their diet, it simply depressed body weights, but there were no other clinical signs of toxicity, as were observed in several studies. From 1992 to 2005 years, thirty-one published articles had been investigating a causal association between PPD and cancer . Associations between personal hair dye use and non-Hodgkin's lymphoma, multiple myeloma, acute leukemia, and bladder cancer  were observed in at least one well-designed study with detailed exposure assessment, but were not consistently observed across studies. 
Hazard Codes: T,N,T+,Xn
Risk Statements: 23/24/25-36-43-50/53-63-36/37/38-45-40 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R36:Irritating to eyes. 
R43:May cause sensitization by skin contact. 
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R63:Possible risk of harm to the unborn child. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R45:May cause cancer. 
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 28-36/37-45-60-61-28A-24/25-23-53 
S28:After contact with skin, wash immediately with plenty of soap-suds. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S60:This material and its container must be disposed of as hazardous waste. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets. 
S24/25:Avoid contact with skin and eyes. 
S23:Do not breathe vapour. 
S53:Avoid exposure - obtain special instructions before use.
RIDADR: UN 1673 6.1/PG 3
WGK Germany: 3
RTECS: SS8050000
F: 8-10-23
HazardClass: 6.1
PackingGroup: III
HS Code: 29215119

Standards and Recommendations：

 

Analytical Methods：