CAS No.:79902-63-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 5gm/kg (5000mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990.
mouse	LD50	intraperitoneal	798mg/kg (798mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990.
mouse	LD50	oral	3gm/kg (3000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990.
mouse	LD50	subcutaneous	1009mg/kg (1009mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990.
rat	LD50	intraperitoneal	705mg/kg (705mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990.
rat	LD50	oral	4438mg/kg (4438mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990.
rat	LD50	subcutaneous	672mg/kg (672mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990.
women	LDLo	oral	108mg/kg/77W- (108mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Australian and New Zealand Journal of Medicine. Vol. 25, Pg. 745, 1995.
women	TDLo	oral	2800ug/kg/7D- (2.8mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: LIVER FUNCTION TESTS IMPAIRED	Medical Journal of Australia. Vol. 155, Pg. 61, 1991.

Consensus Reports：

 

SAFETY PROFILE：

Safty information about Simvastatin (CAS NO.79902-63-9) is:
Hazard Codes: Xi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
RIDADR: 3077
RTECS: EK7798000
HazardClass: 9
PackingGroup: III

Standards and Recommendations：

 

Analytical Methods：